Published

Quality characteristic of instant rice produced using microwave-assisted hot air drying

It is of utmost importance for the instant rice processing sector to reassess its methodologies to enhance the overall quality of instantized rice products. This study aimed to analyze how the combination of microwave (MW) drying and convective …

Constructing two-level $Q_B$-optimal screening designs using mixed-integer programming and heuristic algorithms

Two-level screening designs are widely applied in manufacturing industry to identify influential factors of a system. These designs have each factor at two levels and are traditionally constructed using standard algorithms, which rely on a …

Systematic enumeration of two-level even-odd designs of strength 3

The first dedicated algorithm to enumerate even-odd designs of strength 3 is presented. Such designs cannot be constructed by folding over smaller designs, but they may permit simultaneous estimation of many more two-factor interactions than designs …

Systematic enumeration of definitive screening designs

Conference designs are $n \times k$ matrices, $k < n$, with orthogonal columns, one zero in each column, at most one zero in each row, and $−1$ and $+1$ entries elsewhere. Conference designs with $k = n$ are called conference matrices. Definitive …

Superinfection exclusion factors drive a history-dependent switch from vertical to horizontal phage transmission

Temperate bacterial viruses are commonly thought to favor vertical (lysogenic) transmission over horizontal (lytic) transmission when the virion-to-host-cell ratio is high and available host cells become scarce. In P22-infected Salmonella Typhimurium …

Model Selection Reveals the Butyrate-Producing Gut Bacterium Coprococcus eutactus as Predictor for Language Development in 3-Year-Old Rural Ugandan Children

Introduction: The metabolic activity of the gut microbiota plays a pivotal role in the gut-brain axis through the effects of bacterial metabolites on brain function and development. In this study we investigated the association of gut microbiota …

Two-level orthogonal screening designs with 80, 96, and 112 runs, and up to 29 factors

Due to recent advances in the development of laboratory equipment, large screening experiments can now be conducted to study the joint impact of up to a few dozen factors. While much is known about orthogonal designs involving 64 and 128 runs, there …

A mixed integer optimization approach for model selection in screening experiments

After completing the experimental runs of a screening design, the responses under study are analyzed by statistical methods to detect the active effects. To increase the chances of correctly identifying these effects, a good analysis method should …

A nonlinear multidimensional knapsack problem in the optimal design of mixture experiments

Mixture experiments usually involve various constraints on the proportions of the ingredients of the mixture under study. In this paper, inspired by the fact that the available stock of certain ingredients is often limited, we focus on a new type of …

Projections of Definitive Screening Designs by Dropping Columns: Selection and Evaluation

Definitive screening designs permit the study of many quantitative factors in a few runs more than twice the number of factors. In practical applications, researchers often require a design for m quantitative factors, construct a definitive screening …