Temperate bacterial viruses are commonly thought to favor vertical (lysogenic) transmission over horizontal (lytic) transmission when the virion-to-host-cell ratio is high and available host cells become scarce. In P22-infected Salmonella Typhimurium …
Introduction: The metabolic activity of the gut microbiota plays a pivotal role in the gut-brain axis through the effects of bacterial metabolites on brain function and development. In this study we investigated the association of gut microbiota …
Due to recent advances in the development of laboratory equipment, large screening experiments can now be conducted to study the joint impact of up to a few dozen factors. While much is known about orthogonal designs involving 64 and 128 runs, there …
After completing the experimental runs of a screening design, the responses under study are analyzed by statistical methods to detect the active effects. To increase the chances of correctly identifying these effects, a good analysis method should …
Mixture experiments usually involve various constraints on the proportions of the ingredients of the mixture under study. In this paper, inspired by the fact that the available stock of certain ingredients is often limited, we focus on a new type of …
Definitive screening designs permit the study of many quantitative factors in a few runs more than twice the number of factors. In practical applications, researchers often require a design for m quantitative factors, construct a definitive screening …
This paper tackles the problem of minimising the direct server costs of complex multiple-server queueing systems while improving the quality perceived by customers. The problem is solved by finding the server roster, defined as the allocation of …
Two-level orthogonal arrays of strength 3 permit the study of the main effects and the two-factor interactions of the experimental factors. These arrays are classified into regular and nonregular designs. Good regular designs are available in the …
The best demonstration of the ruggedness of a method is monitoring its performance on an ongoing basis as part of the analytical quality control applied in the laboratory. However, an initial demonstration of the ruggedness is often performed as one …