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Prompt engineering using order-of-addition experiments: An application to generating two-level fractional factorial designs

Large language models (LLMs) are becoming ubiquitous in engineering and science because they can turn prompts into data analysis code, experimental designs, formulations of optimization problems, among other applications. However, many LLMs suffer …

Optimizing Two-Arm Clinical Trials for Personalized Medicine using Integer Programming and Heuristic Algorithms

Subjects with complex diseases, such as malaria and leukemia, can have adverse reactions to the best-known treatments. The personalized medicine approach becomes beneficial because the subjects’ covariates are considered before a treatment …