Subjects with complex and serious diseases, such as malaria and leukemia, can have adverse reactions to the best-known treatments. The personalized medicine approach becomes beneficial because the subjects’ characteristics or covariates are …
Orthogonal minimally aliased response surface (OMARS) designs permit the study of quantitative factors at three levels using an economical number of runs. In these designs, the linear effects of the factors are neither aliased with each other nor …