Subjects with complex and serious diseases, such as malaria and leukemia, can have adverse reactions to the best-known treatments. The personalized medicine approach becomes beneficial because the subjects’ characteristics or covariates are …
Orthogonal minimally aliased response surface (OMARS) designs permit the study of quantitative factors at three levels using an economical number of runs. In these designs, the linear effects of the factors are neither aliased with each other nor …
Modern randomization methods in clinical trials are invariably adaptive, meaning that the assignment of the next subject to a treatment group uses the accumulated information in the trial. Some of the recent adaptive randomization methods use …
Introduction: The metabolic activity of the gut microbiota plays a pivotal role in the gut-brain axis through the effects of bacterial metabolites on brain function and development. In this study we investigated the association of gut microbiota …
Due to recent advances in the development of laboratory equipment, large screening experiments can now be conducted to study the joint impact of up to a few dozen factors. While much is known about orthogonal designs involving 64 and 128 runs, there …